The Centre for Aging Medicine currently consists of one chief scientist, four senior scientists, five researchers, one chief physician and one associate researcher, will provide ongoing high-level clinical translation and cutting-edge multidisciplinary collaboration.
Professor of Institute of Respiratory Diseases, Zhejiang University. Doctoral supervisor, Winner of National Science Fund for Excellent Young Scholars. Vice president of the fourth affiliated hospital Zhejiang University School of Medicine. Vice president of International School of Medicine, Zhejiang University.
Songmin Ying has long been dedicated in studies of molecular mechanism, Pathology regulation and targeting therapy of diseases of respiratory system. His research focus on molecular regulation mechanism of genomic stability of Respiratory tumors and has made advances in chronic airway inflammation targeted therapy. Recent studies have been published in well-known academic journals as corresponding author and first author, including Nature, Nat. Cell Biol., Mol. Cell, Nat. Chem. Biol., Cell Res., Adv. Sci., Sci. Adv., Nat. Commun., Cell Disc., STTT, Nucleic Acids Res., JACI, Biomaterials, Cancer Res., and EMBO Rep. The total cited times is more than 4000. Songmin Ying was invited to be a member of ERS College of Experts, and served as a reviewer of Worldwide Cancer Research、 British Lung Foundation、Marie Sklodowska-Curie Fellowship Programme、Danish Council for Independent Research and Czech Science Foundation.
Associate Professor of Zhejiang University School of Medicine. Doctoral supervisor. Deputy dean of Chu Kochen Honors college.
Jiangtao Guo earned a doctoral degree at University of Chinese Academy of Sciences, a bachelor's degree at college of life science Zhejiang University. He was a postdoctoral fellow at University of Texas Southwestern Medical Center/Howard Hughes Medical Institute. Jiangtao Guo research group is focused on studying structures and mechanisms of ion channels、transport proteins and other membrane proteins through biophysical or biochemical methods such as Cryoelectron microscopy, X-ray crystallography. Jiangtao Guo research group has made a series of outstanding achievements in the field of structural biology of ion transmembrane transportation recently. Related studies have been published in well-known academic journals as corresponding author and first author, including Nature, Science, Sci. Adv., Cell Res., Cell Rep., Nat. Commun., and P. NATL. ACAD. SCI USA.
Researcher in the Department of Biophysics, Medicine School of Zhejiang University. National Outstanding Youth. Doctoral supervisor. Assistant to the dean of the School of Medicine (double specialty program), and Vice Chairman of the Department of Biophysics, School of Basic Medicine. Deputy Secretary-General of Ion Channel and Receptor Branch of Chinese Neuroscience Society.
Fan yang specializes in the functional and dynamic conformational changes of membrane proteins, as well as the rational design of biological macromolecules based on the three-dimensional structure of proteins. Focusing on the TRP channel of stimulus perception, the dynamic gating mechanism of TRPV1 and TRPM8 channels activated by physical and chemical factors such as low temperature, high temperature, capsaicin, menthol and polypeptide macromolecules has been deeply studied, and the regulatory molecules with analgesic effect against TRPV1 channel have been developed. Recent studies have been published in well-known academic journals as corresponding author and first author (including co-author), including Nature, Nat. Chem. Biol., Sci. Transl. Med., Nat. Commun., P. NATL. ACAD. SCI USA, Adv. Sci., Sci. Adv., and PloS Biol. Also has served as reviewer for journals such as J. Neurophysiol., J. Cell. Physiol., and Mol. Cell. Endocrinol.
Professor, Doctoral supervisor and Principal Investigator, School of Brain Science and Brain Medicine, Medicine School of Zhejiang University.
Lijun Kang graduated from Central China Normal College in 1996. As a teacher in Wuhan Institute of BioEngineering from 1996 to 2000. Received PhD from Huazhong University of Science and Technology and studied under Xu Tao, an academician of the Chinese Academy of Sciences. Subsequently, engaged in postdoctoral research in Max-Planck Institute of Biophysics and Chemistry, Germany, Professor Erwin Neher (1991 Nobel Prize winner), Professor Jakob Sorensen's laboratory and Professor X.Z.Sullivan Xu's laboratory, University of Michigan Life Science Institute, USA. In 2011, joined Medicine School of Zhejiang University.
Lijun Kang specializes in the molecular mechanism of sensory perception formation, as well as the drug regulation of sensory disorders caused by genetic defects and aging. Recent studies have been published in well-known academic journals as corresponding author and first author (including co-author), including Cell, Cell Metab., Neuron, Nat. Neurosci., Nat. Aging, Nat. Commun., Nat. Struct. Mol. Biol., and EMBO J. The research have been widely cited by international famous academic journals such as Cell, Nature, Science.
Aging Medicine Center’s research fields include: physiologic aging and premature aging, the pathogenesis of aging-related diseases, assessment and management of geriatric health and intervention therapies for aging.
We attempting to reveal the pathogenesis of aging-related diseases, and elucidate the tissue-specific mechanism of environmental effects on subhealth and frailty of the elderly, including effects of intestinal microecology, toxin, nutrition and aerobic metabolism imbalance on muscle weakness and other physical disorders. We also investigate mechanism of neuron-specific aging including microelements, lipid metabolism, proteases, degeneration and degradation of macromolecules, organelle stress and replicative aging.
Dynamic monitoring, early warning, assessment and management of elderly health.
Developing intervention therapies for aging and aging-related diseases, including immunotherapy technologies, novel multifunctional molecular imaging probes, antibody-conjugated drugs and small molecular drug targeting technology, biomimetic materials, transplantation of mesenchymal stem cells or mesenchymal stem cell-derived organelles and senolytic gene therapy.
The aim is to discover biology laws for aging, reveal the regulatory mechanism of organ aging and to develop new therapies for aging and aging-related diseases.