China, as a country with large population, possesses abundant and diverse human genome resources, which are valuable to researches in human evolution and disease-related genes. However, progress in the study of genomic medicine based on human genome resources in China is relatively lagging behind. Combining genomics and medicine, comprehensively performing in-depth genomic medicine research can effectively determine the pathogenic loci of various diseases, and thereby develop appropriate diagnosis and treatment strategies. The Genomic Medicine Center will impel the effective protection and rational utilization of Chinese genetic resources and build the first international high-level genomic medicine platform along the “Belt and Road”. We aim at providing critical reference data for Asian especially the Chinese population and driving the researches of precise disease genome map and pathogenic mechanism. Meanwhile we will provide competitive talents and industrialization foundation for follow-up genetic diagnosis, biomedical research and precision medicine, and also promote China’s scientific research, technology transformation and public health, and avoid “stuck necks” in the field of medicine and health.