The Center for RNA Medicine (CRM) is physically localized at The International Institutes of Medicine, Zhejiang University, Yiwu, China, with > 5000 square meter area renovated for RNA research. The center is led by vice present Dr. Tianhua Zhou and focuses on paving the way to apply RNA therapeutics in humans. CRM seeks to open a new era of RNA medicine in the clinical diagnosis and treatment of human complex diseases. CRM is in the process of recruiting 15-20 tenure-tracked faculty at the full, associate, and assistant professor stages and 30-40 research-tracked faculty, as well as purchasing equipment of up to 20 million RMB. Currently, we have purchased Bruker Avance III™ HD 500 MHz, Malvern NanoSight NS300, IZON Exoid, Zeiss Axio Imager Z2, JASCO J-1700 Circular Dichroism, BECKMAN XPN100 Ultracentrifuge, LI-COR Odyssey CLx, BR-188 Density Gradient Fractionation System, ZEISS SteREO Discovery.V20, Eppendorf Microinjection System, and Beckman Optima MAX-XP. While Agilent 6125 LC/MS and Agilent 1290-6545XT are pending. Based on the above, CRM intends to adopt a dynamic, multi-scale, and multi-dimensional systematic research approach to explore a series of new targets such as RNA and its peptide derivatives that play a key role in critical human diseases such as tumors and rare genetic diseases, and develop new RNA drugs and mRNA vaccines for tumors and rare genetic diseases, and focus on solving the bottleneck of RNA delivery system in vivo to start a new journey of RNA medicine in the clinical diagnosis and treatment of complex human diseases. We aim to set up multi-interdisciplinary platforms for fundamental and translational research, becoming a leading RNA center worldwide.