Population aging has become a serious problem that the whole world facing and has long-term effect on development of human society. In 2018, for the first time in history, persons aged 65 or above outnumbered children under five years of age globally. The number of persons aged 80 years or over is projected to triple, from 143 million in 2019 to 426 million in 2050. The primary problem brought by population aging is the high incidence of aging-related diseases. Therefore, basic research on common mechanism of organ aging is of great importance.